Holopedium gibberum - an indicator of soft-water lakes? [Translation from: Fauna 21 130-132, 1968.]

In fresh waters the planktonic Crustacea are represented mainly by the two large groups, the Copepoda and the Cladocera. This study focuses on Holopedium gibberum and examines if the plankton is an indicator of soft-water lakes. H. gibberum is found throughout the northern half of the globe but its distribution is scattered and irregular. The study is based on a literature review and samples taken from water bodies in Norway

Open String/Open D-Brane Dualities: Old and New

We examine magnetic and electric near horizon regions of maximally supersymmetric D-brane and NS5-brane bound states and find transformations between near horizon regions with worldvolume dual magnetic and electric fluxes. These point to dual formulations of NCYM, NCOS and OD$p$ theories in the limit of weak coupling and large spatial or temporal non-commutativity length scale in terms of weakly coupled theories with fixed worldvolume dual non-commutativity based on open D-branes. We also examine the strong coupling behavior of the open D-brane theories and propose a unified web of dualities involving strong/weak coupling as well as large/small non-commutativity scale.Comment: 33 pages, Latex, 8 diagrams, added references and a remar

Effects of a nonadiabatic wall on supersonic shock/boundary-layer interactions

Direct numerical simulations are employed to investigate a shock wave impinging on a turbulent boundary layer at free-stream Mach number M=2.28 with different wall thermal conditions, including adiabatic, cooled, and heated, for a wide range of deflection angles. It is found that the thermal boundary condition at the wall has a large effect on the size of the interaction region and on the level of pressure fluctuations. The distribution of the Stanton number shows a good agreement with prior experimental studies and confirms the strong heat transfer and complex pattern within the interaction region. An effort was also made to describe the unsteady features of the flow by means of wall pressure and heat flux spectra. Numerical results indicate that the changes in the interaction length due to the wall thermal condition are mainly linked to the incoming boundary layer, which is in agreement with previous experimental studies

Reducing the Bias of Causality Measures

Measures of the direction and strength of the interdependence between two time series are evaluated and modified in order to reduce the bias in the estimation of the measures, so that they give zero values when there is no causal effect. For this, point shuffling is employed as used in the frame of surrogate data. This correction is not specific to a particular measure and it is implemented here on measures based on state space reconstruction and information measures. The performance of the causality measures and their modifications is evaluated on simulated uncoupled and coupled dynamical systems and for different settings of embedding dimension, time series length and noise level. The corrected measures, and particularly the suggested corrected transfer entropy, turn out to stabilize at the zero level in the absence of causal effect and detect correctly the direction of information flow when it is present. The measures are also evaluated on electroencephalograms (EEG) for the detection of the information flow in the brain of an epileptic patient. The performance of the measures on EEG is interpreted, in view of the results from the simulation study.Comment: 30 pages, 12 figures, accepted to Physical Review

Corporate Financing in Great Britain

Background: The antifungal compound ketoconazole has, in addition to its ability to interfere with fungal ergosterol synthesis, effects upon other enzymes including human CYP3A4, CYP17, lipoxygenase and thromboxane synthetase. In the present study, we have investigated whether ketoconazole affects the cellular uptake and hydrolysis of the endogenous cannabinoid receptor ligand anandamide (AEA). Methodology/Principal Findings: The effects of ketoconazole upon endocannabinoid uptake were investigated using HepG2, CaCo2, PC-3 and C6 cell lines. Fatty acid amide hydrolase (FAAH) activity was measured in HepG2 cell lysates and in intact C6 cells. Ketoconazole inhibited the uptake of AEA by HepG2 cells and CaCo2 cells with IC50 values of 17 and 18 mu M, respectively. In contrast, it had modest effects upon AEA uptake in PC-3 cells, which have a low expression of FAAH. In cell-free HepG2 lysates, ketoconazole inhibited FAAH activity with an IC50 value (for the inhibitable component) of 34 mu M. Conclusions/Significance: The present study indicates that ketoconazole can inhibit the cellular uptake of AEA at pharmacologically relevant concentrations, primarily due to its effects upon FAAH. Ketoconazole may be useful as a template for the design of dual-action FAAH/CYP17 inhibitors as a novel strategy for the treatment of prostate cancer